Methyl iodide → HCID 19075336, compound

HRID 1975109Notes

Reaction equation

HRID 1975109 reaction equation
[CH3:1][I:2].[CH2:3]([O:6][C:7]1[C:8]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[N:9][S:10][N:11]=1)[C:4]#[CH:5]>CC(C)=O>[I-:2].[CH2:3]([O:6][C:7]1[C:8]([C:12]2[CH:13]=[N+:14]([CH3:1])[CH:15]=[CH:16][CH:17]=2)=[N:9][S:10][N:11]=1)[C:4]#[CH:5]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19075253HCID 19075253, compound

Product 1

HCID 19075336HCID 19075336, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.45 ml, 7.2 mmol) and 3-(4-propargyloxy-1,2,5-thiadiazol-3-yl)pyridine (430 mg, 2.4 mmol) in acetone (5 ml) was stirred at room temperature for 18 h. The title compound precipitated from the solution and was collected by filtration to yield 0.58 g (67%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration
  3. customto yield 0.58 g (67%)

Sources & evidence

ORD record
ord-8e72a6cbde2b43409667b16f43e78760
Source dataset
uspto-grants-1994_02
Patent number
US05284859

Reaction notes

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