HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(3-(3-Methyl-2-butenyloxy)-1,2,5-thiadiazol-4-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Methyl-2-buten-1-OL | HCID 11173 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole | HCID 10488164 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3-(3-Methyl-2-butenyloxy)-1,2,5-thiadiazol-4-yl)pyridine | HCID 19075325 | — |
Reaction Steps
To a solution of 3-methyl-2-buten-1-ol (780 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 0.3 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05284859 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-2bfbe7804a544923991b33c7a27228f3 |
| Source note | uspto-grants-1994_02 |