Water → HCID 67655879, compound

HRID 1975189Notes

Reaction equation

HRID 1975189 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][S:11]([C:14]([F:17])([F:16])[F:15])(=[O:13])=[O:12])=[CH:5][CH:4]=1.[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH2:24])[CH3:20].O>C1(C)C=CC=CC=1>[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH:24][C:9](=[CH:10][S:11]([C:14]([F:17])([F:16])[F:15])(=[O:13])=[O:12])[C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[CH3:20]

Participants

5

Reactant 3

HCID 962WaterHCID 695242,2-DiethoxyethylamineHCID 10085154HCID 10085154, compound

Product 1

HCID 67655879HCID 67655879, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 4'-methoxy-2-[(trifluoromethyl)sulfonyl]acetophenone (6.0 g, 0.021 mol) in toluene is treated with aminoacetaldehyde diethyl acetal (2.8 g, 0.021 mol), heated at reflux overnight with removal of water, and concentrated in vacuo to obtain the title product as an oil. This oil is used in Example 4 without further purification.

Workup

  1. temperatureheated
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-55b07444de8847be97c7bf2de27cc3b2
Source dataset
uspto-grants-1994_02
Patent number
US05284863

Reaction notes

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