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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 197522Generated: October 30, 2026

Tetrahydrofuran → 4'-{2-[1-(2-acetylamino-ethylcarbamoyl)-1-methyl-ethoxy]-5-chloro-phenyl}-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

https://huagongshe.com/reaction/197522

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantN-(2-aminoethyl)acetamideHCID 66082—
Reactant1-HydroxybenzotriazoleHCID 75771—
ReactantDiisopropylethylamineHCID 81531—
Reactant6-chloro-4'-[5-chloro-2-(2-hydroxy-1,1-dimethyl-ethoxy)phenyl]-2'-[5-fluoro-2-methylphenyl]spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dioneHCID 76567885—
Product4'-{2-[1-(2-acetylamino-ethylcarbamoyl)-1-methyl-ethoxy]-5-chloro-phenyl}-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dioneHCID 74928686—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
ORD IDord-24976321d25b4ec4b6879f3f0826e9c1
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (6/10)