2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline → 5-fluoro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

HRID 197523Notes

Reaction equation

HRID 197523 reaction equation
[CH3:19][O:20][c:21]1[c:22]([NH2:23])[cH:24][cH:25][c:26]([N:28]2[CH2:29][CH2:30][CH:31]([N:34]3[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]3)[CH2:32][CH2:33]2)[cH:27]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([F:18])[c:6](-[c:8]2[cH:9][n:10]([CH3:17])[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1>>[c:2]1([NH:23][c:22]2[c:21]([O:20][CH3:19])[cH:27][c:26]([N:28]3[CH2:29][CH2:30][CH:31]([N:34]4[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]4)[CH2:32][CH2:33]3)[cH:25][cH:24]2)[n:3][cH:4][c:5]([F:18])[c:6](-[c:8]2[cH:9][n:10]([CH3:17])[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1

Participants

3

Reactant 2

HCID 457899912-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)anilineHCID 580715123-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole

Product 1

HCID 580714345-fluoro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-6b3a64ff5edf44cdb4fd7e54370589c1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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