2-Amino-4,6-dimethoxypyrimidine → HCID 10939226, compound

HRID 1975230Notes

Reaction equation

HRID 1975230 reaction equation
CN([C:7]1[CH:8]=[C:9]2[S:15](=[O:17])(=[O:16])[NH:14][C:13](=[O:18])[N:10]2[CH2:11][CH:12]=1)S(C)(=O)=O.[NH2:19][C:20]1[N:25]=[C:24]([O:26][CH3:27])[CH:23]=[C:22]([O:28][CH3:29])[N:21]=1>ClCCl>[CH3:27][O:26][C:24]1[CH:23]=[C:22]([O:28][CH3:29])[N:21]=[C:20]([NH:19][C:13](=[O:18])[NH:14][S:15]([C:9]2[C:8]([N:14]([CH3:13])[S:15]([CH3:9])(=[O:17])=[O:16])=[CH:7][CH:12]=[CH:11][N:10]=2)(=[O:16])=[O:17])[N:25]=1

Participants

4

Reactant 2

HCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 19101092HCID 19101092, compound

Product 1

HCID 10939226HCID 10939226, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.9 g (10 mmol) of the compound (II-1) (Example 1) and 1.55 g (10 mmol) of 2-amino-4,6-dimethoxypyrimidine are combined in 30 ml of dichloromethane and refluxed for 8 hours. After the solvent has been removed in vacuo, 4.45 g (100% of theory) of 3-(4,6-dimethoxypyrimidin-2-yl)-1-[3-(N-methyl-N-methylsulfonylamino)-2-pyridylsulfonyl]-urea of m.p. 168°-173° C. (decomp.) are obtained in a purity of approx. 90%.

Workup

  1. temperaturerefluxed for 8 hours
  2. customAfter the solvent has been removed in vacuo, 4.45 g (100% of theory) of 3-(4,6-dimethoxypyrimidin-2-yl)-1-[3-(N-methyl-N-methylsulfonylamino)-2-pyridylsulfonyl]-urea of m.p. 168°-173° C. (decomp.)
  3. customare obtained in a purity of approx. 90%

Sources & evidence

ORD record
ord-25522f9d87264b7fa7e98999bc57e56b
Source dataset
uspto-grants-1994_02
Patent number
US05284945

Reaction notes

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