HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1975252Generated: November 1, 2026
Acetonitrile → Ethyl 2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
https://huagongshe.com/reaction/1975252
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thioacetamide | HCID 2723949 | — |
| Reactant | Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate | HCID 2737165 | — |
| Product | Ethyl 2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate | HCID 1486077 | — |
Reaction Steps
A solution of thioacetamide in acetonitrile (6.66 mol), prepared as in Example 1, is placed in a flask. Ethyl 2-chloro-4,4,4-trifluoroacetoacetate (5.06 mol) is added and an exotherm is observed. Triethylamine (13.64 mol) is added and the mixture is heated to reflux (approx. 76° C.) for one hour. The resulting solution is cooled. Ethyl 2-methyl-4-(trifluoromethyl)-thiazole-5-carboxylate may be isolated by standard means.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05284974 |
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| Source dataset | uspto-grants-1994_02 |
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| ORD ID | ord-5b1b2afce5314600b8e122f70864cfbe |
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| Source note | uspto-grants-1994_02 |
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