HCID 19101398, compound → HCID 9957292, compound

Participants

Reaction Steps

A suspension of methyl 3,5-dibromo-4-(4-hydroxy-3-isopropylphenylsulfonyl)phenylacetate (2.7 g, 0.0053 mol), from Example 2, in 30 mL sodium hydroxide (5%) was heated at 60° C. for 10 min. The reaction mixture was cooled and extracted with ethyl acetate. The aqueous phase was acidified with hydrochloric acid (6N) and extracted with ethyl acetate (2X). The combined extract was washed with water and brine and dried (Na2SO4). The residue obtained after removal of the solvent was crystallized from hexane-ethyl acetate to obtain 3,5-dibromo-4-(4-hydroxy-3-isopropylphenylsulfonyl)phenylacetic acid (2.5 g, 0.0051 mol, 96% yield), MP: 171°-172° C.

Provenance & Evidence