Potassium Hydroxide → HCID 9870822, compound

HRID 1975263Notes

Reaction equation

HRID 1975263 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:23][C:24]([O:26]C)=[O:25])[CH:5]=[C:6]([Br:22])[C:7]=1[S:8]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([CH:19]([CH3:21])[CH3:20])[CH:12]=1)(=[O:10])=[O:9].[OH-].[K+]>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH2:23][C:24]([OH:26])=[O:25])[CH:5]=[C:6]([Br:22])[C:7]=1[S:8]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([CH:19]([CH3:21])[CH3:20])[CH:12]=1)(=[O:9])=[O:10]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 19101407HCID 19101407, compound

Product 1

HCID 9870822HCID 9870822, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 3,5-dibromo-4-(3-isopropyl-4-methoxyphenylsulfonyl)phenylacetate (0.6 g), prepared by the method of Example 1, was treated with KOH in 10% aqueous MeOH for 0.5 hour, acidified and the product collected by filtration, washed with water, and dried in a vacuum oven to yield 3,5-dibromo-4-(3-isopropyl-4-methoxyphenylsulfonyl)phenylacetic acid. MP 170°-173° C.

Workup

  1. filtrationthe product collected by filtration
  2. washwashed with water
  3. customdried in a vacuum oven

Sources & evidence

ORD record
ord-292126cab0a14c1ea93bf7df71ba8ef5
Source dataset
uspto-grants-1994_02
Patent number
US05284971

Reaction notes

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