Silica → Diltiazem

HRID 1975293Notes

Reaction equation

HRID 1975293 reaction equation
[CH3:1][C:2]([O:4][C@H:5]1[C:15](=[O:16])[N:14]([CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[S:7][C@H:6]1[C:22]1[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=1)=[O:3].Cl.C(O)(=O)/C=C/C(O)=O.[Si](=O)=O>>[CH3:1][C:2]([O:4][C@H:5]1[C:15](=[O:16])[N:14]([CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[S:7][C@H:6]1[C:22]1[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=1)=[O:3]

Participants

4

Reactant 3

HCID 24261SilicaHCID 62920Diltiazem Hydrochloride2×HCID 444972Fumaric Acid

Product 1

HCID 39186Diltiazem

Procedure

To an 80 cubic foot blender is charged 188 kg of diltiazem HCl, 94.0 kg of fumaric acid NF, 94 kg of talc, 2.8 kg of silicon dioxide, and an additional 188 kg of diltiazem HCl. The mixture is dry blended for 15 minutes and then milled through a 0.013 inch screen.

Workup

  1. customThe mixture is dry blended for 15 minutes
  2. custommilled through a 0.013 inch screen

Sources & evidence

ORD record
ord-60aca50807ee408fae9b6de81ba0990e
Source dataset
uspto-grants-1994_02
Patent number
US05286497

Reaction notes

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