Xaliproden hydrochloride → HCID 19099578, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride (5 g, 0.012 mol), 10% Pd/C (0.6 g) and 95% ethanol (130 ml) are charged into a hydrogenation reaction vessel and hydrogenated, under stirring, at 50° C. for 3 hours. The catalyst is then removed by filtration and the filtrate is concentrated to dryness. The residue is triturated with a small amount of diethyl ether and the white solid which is obtained therefrom by filtration is crystallised from absolute ethanol (120 ml) and dried affording 3.5 g (0.0083 mol) of 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)piperidine hydrochloride. M.p. 296°-298° C.

Provenance & Evidence