Sodium hydride → HCID 10705792, compound

Participants

Reaction Steps

To a stirred suspension of n-hexane-washed sodium hydride (0.94 g, 39.0 mmol, 1.3 eq) there was added a solution of ethoxyethyl 2-oxocyclopentane-carboxylate (4.26 g, 30.0 mmol, 1.0 eq) in DMF (15 ml) at 0° C. The resulting solution was warmed to room temperature and then stirred for 30 min: the solution became orange. After terminal evolution of hydrogen had been confirmed, p-fluorobenzyl bromide (6.80 g, 36.0 m mol, 1.2 eq) was added to the resulting solution at 0° C. The reaction mixture was then warmed to room temperature and stirred overnight.

Provenance & Evidence