Sodium hydride → HCID 10727826, compound

Participants

Reaction Steps

Trimethylsulfoxonium iodide (4.86 g, 22.1 mmol, 1.3 eq) was dissolved in DMSO (25 ml) and sodium hydride (0.49 g, 20.4 mmol, 1.2 eq) was added at 100° C. while being stirred. The solution was warmed to room temperature and stirred for 45 min while being stirred; thereafter, the solution became transparent. After terminal evolution of hydrogen had been confirmed, the solution was again heated at 10° C. and 2-(2,4-difluorobenzyl)cyclopentanone (3.56 g, 17.0 mmol, 1.0 eq) was dripped into the solution.

Provenance & Evidence