Dimethyl Sulfoxide → HCID 10450969, compound

Participants

Reaction Conditions

Reaction Steps

200 mg of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 200 mg of crude 4,7-diazaspiro[2,5]octane 25 were added to 10 ml of dimethyl sulfoxide followed by the addition of 0.3 ml of triethylamine. The mixture was heated on a bath of 120° C. for 2 hours. The solvent was then removed under reduced pressure and the residue was subjected to silica gel column chromatography, eluting with chloroform-methanol-water=15:3:1 (v/v). The crude product obtained from the fraction containing the desired compound was recrystallized from ethanol-concentrated aqueous ammonia to give 160 mg of title compound 37.

Provenance & Evidence