HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 19020587, compound → 1-(4-Aminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 19020587 | HCID 19020587 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Aminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine | HCID 18946357 | 87.7% |
Reaction Steps
37.2 g of 1-(4-nitrobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine are reduced at room temperature in 370 ml of tetrahydrofuran in the presence of 20 g of Raney nickel. The filtered reaction solution is concentrated by evaporation and the resulting oil is crystallised from isopropanol/petroleum ether, yielding 30 g of 1-(4-aminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine having a melting point of 111°-112°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286728 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-788c09c380c14357b10a53bccc2e60ec |
| Source note | uspto-grants-1994_02 |