HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-[4-(3-Ethoxypropylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-bromo-3-ethoxypropane | HCID 260493 | — |
| Reactant | 1-(4-Aminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine | HCID 18946357 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-[4-(3-Ethoxypropylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine | HCID 19099427 | — |
Reaction Steps
11 g of 1-(4-aminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine and 5.7 g of 3-ethoxypropyl bromide are suspended in 150 ml of isopropanol and dissolved at 100°. 9.4 g of potash are added thereto, and the mixture is boiled under reflux for 20 hours. Concentration by evaporation and chromatography over silica gel yield an oil, which is crystallised from methylene chloride and petroleum ether, yielding 1-[4-(3-ethoxypropylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine having a melting point of 87°-89°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286728 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-8e0152fa8b7a4eda9ce8432ef410d20a |
| Source note | uspto-grants-1994_02 |