Chloroacetyl chloride → 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine

Participants

Reaction Steps

In a manner analogous to that described in Example 6, the oily 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine is prepared from 1.35 g of 1-[4-(2-isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine by reaction with chloroacetyl chloride; IR (CH2Cl2): 1650 cm-1 (broad); NMR (CDCl3): 1.15 (t, 3H), 1.8 (m, 2H), 2.5 (m) and 2.6 (t) (together 6H), 2.8 (t, 2H), 3.4 (m, 6H), 3.85 (m, 6H), 7.15 (d, 2H), 7.3 (m, 4H), 7.5 ppm (d, 2H).

Provenance & Evidence