HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-[4-(N-chloroacetylamino)benzoyl]-4-(4-chlorobenzyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Chlorobenzylpiperazine | HCID 134826 | — |
| Reactant | 4-Chloroacetylaminobenzoic acid chloride | HCID 13305693 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[4-(N-chloroacetylamino)benzoyl]-4-(4-chlorobenzyl)piperazine | HCID 19099510 | — |
Reaction Steps
2.18 g of 4-chlorobenzylpiperazine are dissolved in 40 ml of absolute tetrahydrofuran. With stirring, 1.73 g of Hunig base and 2.64 g of 4-chloroacetylaminobenzoic acid chloride are added thereto in succession. The internal temperature rises to approximately 38°. After 30 minutes, the solution is concentrated by evaporation. The oily residue is digested with water, yielding 1-[4-(N-chloroacetylamino)benzoyl]-4-(4-chlorobenzyl)piperazine having a melting point of 205°-207°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286728 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-3544597f0f8f4ee7be2d972a26fbb7d7 |
| Source note | uspto-grants-1994_02 |