Chloroacetyl chloride → HCID 19099430, compound

HRID 1975364Notes

Reaction equation

ClCC([NH:5][C:6]1[CH:28]=[CH:27][CH:26]=[CH:25][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[CH2:12][CH2:11]1)=[O:9])=O.ClCC(Cl)=O>>[NH2:5][C:6]1[CH:28]=[CH:27][CH:26]=[CH:25][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[CH2:12][CH2:11]1)=[O:9]

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 19099460HCID 19099460, compound

Product 1

HCID 19099430HCID 19099430, compound

Procedure

In a manner analogous to that described in Example 22, 1-[2-(N-chloroacetylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine having a melting point of 108°-109° is obtained from 2 g of 1-(2-aminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]-piperazine by reaction with chloroacetyl chloride.

Sources & evidence

ORD record: ord-6234fe7bf1194716ab83035f7c6da504
Source dataset: uspto-grants-1994_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05286728

Reaction notes

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