Sodium Hydroxide → HCID 19099437, compound

Participants

Reaction Steps

1.2 g of 1-{4-[N-(2-isopropyloxyethyl)-N-acetoxyacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine (Example 41) are dissolved in 20 ml of ethanol. 1.5 ml of 2N sodium hydroxide solution in 5 ml of water are added thereto, and the mixture is stirred at RT for one hour. After concentration by evaporation, the residue is dissolved in ethyl acetate and washed with water. Concentration by evaporation and treatment with ethereal hydrochloric acid yield 1-{4-[N-(2-isopropyloxyethyl)-N-hydroxyacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 99°-101°.

Provenance & Evidence