Chloroacetyl chloride → HCID 19099487, compound

Participants

Reaction Steps

2.77 g of 1-[3-(2-isopropyloxyethylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine are dissolved in 50 ml of absolute tetrahydrofuran and stirred at RT with 1.07 g of Hunig base and 0.794 g of chloroacetyl chloride in 5 ml of absolute tetrahydrofuran. After approximately 15 minutes, the thin suspension is concentrated by evaporation, dissolved in ethyl acetate and washed with water until neutral. Concentration by evaporation, chromatography of the residue over silica gel (eluant: ethyl acetate) and treatment with ethereal hydrochloric acid yield 1-{3-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 115°-117°.

Provenance & Evidence