HCID 19020615, compound → Hydrochloric Acid

Participants

Reaction Steps

1.9 g of 1-{4-[N-(2-dimethylaminoethyl)-N-benzyloxycarbonylamino]-benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine are hydrogenated in 30 ml of methanol in the presence of 0.4 g of palladium-on-carbon. The mixture is filtered off with suction, concentrated by evaporation, rendered alkaline with 2N NaOH and extracted with ether. The mixture is concentrated by evaporation and recrystallised from ether. The 1-[4-(2-dimethylaminoethylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine melts at 74°-78°. With alcoholic hydrochloric acid, 1-[4-(2-dimethylaminoethylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point >275° is obtained.

Provenance & Evidence