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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1975378Generated: October 26, 2026

1-(4-Bromophenethyl)piperazine → 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-bromophenyl)ethyl]piperazine

https://huagongshe.com/reaction/1975378

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Bromophenethyl)piperazineHCID 19020578—
Reactant4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chlorideHCID 19099416—
Product1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-bromophenyl)ethyl]piperazineHCID 19099449—

Reaction Steps

Analogously to Example 55, 1.5 g of 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride are reacted with 1.07 g of [2-(4-bromophenyl)ethyl]-piperazine, yielding 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-bromophenyl)ethyl]piperazine having a melting point of 92°-93°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05286728
Source datasetuspto-grants-1994_02
ORD IDord-0888416cf7904b3487adac5c4474f696
Source noteuspto-grants-1994_02