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4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride → 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-methylmercaptophenyl)ethyl]piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride | HCID 19099416 | — |
| 反応物 | 1-{2-[4-(Methylsulfanyl)phenyl]ethyl}piperazine | HCID 53859945 | — |
| 生成物 | 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-methylmercaptophenyl)ethyl]piperazine | HCID 54113765 | — |
反応手順
Analogously to Example 55, 1.5 g of 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride are reacted with 0.95 g of [2-(4-methylmercaptophenyl)ethyl]piperazine, yielding 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-methylmercaptophenyl)ethyl]piperazine. The hydrochloride thereof melts at 115°-116°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05286728 |
| 出典データセット | uspto-grants-1994_02 |
| ORD ID | ord-a95fb51f5f154c3baeae945484805b49 |
| 出典メモ | uspto-grants-1994_02 |