HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(4-Methoxyphenyl)ethyl]piperazine → 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-methoxyphenyl)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(4-Methoxyphenyl)ethyl]piperazine | HCID 12235717 | — |
| Reactant | 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride | HCID 19099416 | — |
| Product | 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-methoxyphenyl)ethyl]piperazine | HCID 19099482 | — |
Reaction Steps
Analogously to Example 55, 1.5 g of 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride are reacted with 0.88 g of [2-(4-methoxyphenyl)ethyl]piperazine, yielding 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-methoxyphenyl)ethyl]piperazine. The hydrochloride thereof melts at 139°-140°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286728 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-5ca9a9e8a8ef44308659b304339501ad |
| Source note | uspto-grants-1994_02 |