HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4,4,4-Trifluorobutanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4,4,4-Trifluorobutanoic acid | HCID 2777085 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4,4,4-Trifluorobutanoyl chloride | HCID 15104474 | 85% |
Reaction Steps
Dimethyl formamide (1.0 mL) and oxalylchloride (239 mL) were added to a 0° C. solution of 4,4,4-trifluorobutyric acid (343 g) in dry methylene chloride (230 mL) and warmed to room temperature overnight. The methylene chloride was removed by distillation and the residue distilled to yield 4,4,4-trifluorobutyryl chloride (328 g, 85%); bp 103°-106° C.; partial NMR (300 MHz, CDCl3): 2.47-2.64 (m, 2H, CF3CH2) 3.19 (t, H, CH2COCl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286740 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-2547e74275dd49a79c2804f60b64995d |
| Source note | uspto-grants-1994_02 |