ethyl 2-(N-benzylaminomethyl)-3-t-butyldimethylsilyloxybutanoate → Ethyl 2-aminomethyl-3-t-butyldimethylsilyloxybutanoate

Participants

Reaction Steps

To a solution of 70.2 g of ethyl 2-(N-benzylaminomethyl)-3-t-butyldimethylsilyloxybutanoate in methanol (100 ml) was added portionwise 10.0 g of 10% wet palladium on carbon under nitrogen atmosphere. The mixture was shaken vigorously under 3.5 atmospheric pressure of hydrogen. After 8 hours, palladium on carbon was filtered off and washed with chloroform. The filtrate was evaporated to dryness under reduced pressure to give 50.3 g of crude ethyl 2-aminomethyl-3-t-butyldimethylsilyloxybutanoate.

Provenance & Evidence