Water → (2-Methylpyridin-3-yl)methanol

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (6.2 g) in tetrahydrofuran (400 ml) was added dropwise ethyl 2-methylnicotinate (25 g) at -20° C. After stirring for 1 hour, to the reaction mixture was added dropwise in turn water (6.2 ml), 4N-aqueous sodium hydroxide (6.2 ml) and water (18.6 ml). The precipitate was filtered off and the filtrate was concentrated in vacuo to give 3-hydroxymethyl-2-methylpyridine (16.2 g).

Provenance & Evidence