Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(Methylsulfanyl)pyridine-3-carbonyl chloride | HCID 2774517 | — |
| Reactant | Aminoacetonitrile hydrochloride | HCID 11491918 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19099326 | HCID 19099326 | 89.6% |
Reaction Steps
To a stirred solution of aminoacetonitrile hydrochloride (5.95 g) in a mixture of water (100 ml) and tetrahydrofuran (100 ml) was added slowly 2 -(methylthio)nicotinoyl chloride (10 g) at 0° C. while adjusting pH to 8-9 with 4N-aqueous sodium hydroxide. After stirring for 30 minutes at 0° C., the solvent was evaporated to give a residue, which was chromatographed on silica gel (350 ml) eluting with ethyl acetate to give [2-(methylthio)nicotinoyl]aminoacetonitrile (9.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05286721 |
|---|
| Source dataset | uspto-grants-1994_02 |
|---|
| ORD ID | ord-849bb1abe30a4ec0ae06dce5991b1c1f |
|---|
| Source note | uspto-grants-1994_02 |
|---|
