HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → ethyl (2S,3R)-3-t-butyldimethylsilyloxy-2-(methylaminomethyl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | ethyl 2-[(1R)-1-(t-butyldimethylsilyloxy)ethyl]acrylate | HCID 11108029 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | ethyl (2S,3R)-3-t-butyldimethylsilyloxy-2-(methylaminomethyl)butanoate | HCID 57178030 | — |
Reaction Steps
To a solution of ethyl (3R)-3-t-butyldimethylsilyloxy-2-methylidenebutanoate (130 g) in methanol (1.3 l) was added a solution of 30% methylamine in methanol (63 ml). The resulting mixture was allowed to stir at ambient temperature for 2 days. Evaporation of the solvent gave ethyl (2S,3R)-3-t-butyldimethylsilyloxy-2-(methylaminomethyl)butanoate (150.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286721 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-3ddd4a458c2b4f6b86be2eb0cce87887 |
| Source note | uspto-grants-1994_02 |