反应详情

To a solution of 2-cyano-3-hydroxy-1-pentene (10 g) in methanol (100 ml) was added benzylamine (10 ml). After stirring for 8 hours under reflux, the solvent was evaporated, and the residue was chromatographed on silica gel with eluting a mixture of n-hexane and ethyl acetate (1:1, V/V) to give 1-benzylamino-2-cyano-3-hydroxypentane (10 g).

1. temperatureunder reflux
2. customthe solvent was evaporated
3. customthe residue was chromatographed on silica gel
4. washwith eluting
5. additiona mixture of n-hexane and ethyl acetate (1:1, V/V)