反应详情

To a solution of 1-benzylamino-2-cyano-3-hydroxypentane (1.0 g) in 5% ammonia-methanol solution (20 ml) was added Raney Nickel (W2, 5g). After stirring under atmospheric pressure of hydrogen at room temperature for 4 hours, the catalyst was filtered off and to the filtrate were added ammonium formate (1.4 g) and 10% palladium on carbon (1 g, 50% wet). After stirring for 1 hour under reflux, the catalyst was filtered off and the filtrate was evaporated to give 1-amino-2-aminomethyl-3-hydroxypentane (0.91 g).

1. filtrationthe catalyst was filtered off and to the filtrate
2. additionwere added ammonium formate (1.4 g) and 10% palladium on carbon (1 g, 50% wet)
3. temperatureunder reflux
4. filtrationthe catalyst was filtered off
5. customthe filtrate was evaporated