Ammonia → 5-(2-Hydroxyethyl)pyrrolidin-2-one

HRID 1975503Notes

Reaction equation

HRID 1975503 reaction equation
CO[CH:3]1[CH2:10][CH2:9][O:8][C:6](=[O:7])[CH2:5][CH2:4]1.[NH3:11]>>[OH:8][CH2:9][CH2:10][CH:3]1[NH:11][C:6](=[O:7])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 14139812HCID 14139812, compound

Product 1

HCID 108554765-(2-Hydroxyethyl)pyrrolidin-2-one

Procedure

30 g of 4-methoxycaprolactone were stirred at 330° C. for 1 hour together with 100 g of 25% strength aqueous ammonia in the same manner as described in Example 4. After cooling and depressurizing the autoclave and working up the reaction mixture by distillation, 9.1 g of 5-hydroxyethylpyrrolidone were obtained (34%, based on the 4-methoxycaprolactone employed) and identified by NMR spectroscopy.

Workup

  1. temperatureAfter cooling
  2. distillationworking up the reaction mixture by distillation

Sources & evidence

ORD record
ord-ba12bb7415234863b543db073f5e611b
Source dataset
uspto-grants-1994_02
Patent number
US05286875

Reaction notes

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