HCID 54348341, compound → HCID 10261413, compound

Participants

Reaction Steps

That is, the (S)-5,6-dihydroxy-3-oxohexanoic acid derivative shown by formula (2) is dissolved in an alcohol such as methanol, ethanol, iso-propanol, tert-butyl alcohol, etc., the ruthenium-optically active phosphine complex shown by formula (3) is added to the solution in an amount of from 0.0001 to 0.002 mol, and preferably from 0.0001 to 0.001 mol, per mol of the compound of formula (2), the hydrogenation is carried out under a hydrogen pressure of from 10 to 120 kg/cm2, and preferably from 20 to 50 kg/cm2 and at a reaction temperature of from 25° to 100° C., and preferably from 30° to 50° C. The solvent was removed by distillation, and the residue formed is purified by silica gel column chromatography to provide the desired (3R,5S)-3,5,6-trihydroxyhexanoic acid derivative shown by formula (1).

Provenance & Evidence