反应详情

Trimethylaluminum (2.0 M in toluene; 4.6 mi) was added dropwise via syringe to a stirred solution of methyl 3-[(2-furanylmethyl)thio]propanoate (0.75 gram) and 10-(aminoacetyl)-8-chloro-10,11-dihydrodibenz-[b,f][1,4]oxazepine (1.00 gram) in toluene (30 mi) at room temperature under nitrogen, and the reaction was stirred for 5 hours. Methanol (14 mi) was then added, and the reaction was stirred at room temperature overnight. The reaction was evaporated in vacuo, and the resulting orange residue was partitioned between chloroform (50 mi) and 1N NAOH (50 mi). The layers were separated and the aqueous layer was extracted with chloroform (50 mi). The combined chloroform extracts were washed with 1N NAOH (50 mi), 1 N HCl (2 x 50 mi), and brine (50 mi), dried over MgSO4, and evaporated in vacuo. The crude product was purified by flash chromatography through silica gel 60 (350 mi) using 3:1 chloroform:ethyl acetate followed by recrystallization from cyclohexane/ethyl acetate. The yield of the title compound was 0.63 gram (40%) in the form of a tan solid. Analysis calculated for C23H21ClN2O4S: C, 60.46; H, 4.63; N, 6.13; Cl, 7.67; S, 7.02. Found: C, 60.16; H, 4.62; N, 6.05; Cl, 8.06; S, 7.02. DSC: 90°-95° C.

1. stirringthe reaction was stirred at room temperature overnight
2. customThe reaction was evaporated in vacuo
3. customthe resulting orange residue was partitioned between chloroform (50 mi) and 1N NAOH (50 mi)
4. customThe layers were separated
5. extractionthe aqueous layer was extracted with chloroform (50 mi)
6. washThe combined chloroform extracts were washed with 1N NAOH (50 mi), 1 N HCl (2 x 50 mi), and brine (50 mi)
7. dry with materialdried over MgSO4
8. customevaporated in vacuo
9. customThe crude product was purified by flash chromatography through silica gel 60 (350 mi)
10. customethyl acetate followed by recrystallization from cyclohexane/ethyl acetate
11. custom90°-95° C.