Hydrochloric Acid → HCID 19919510, compound

Participants

Reaction Steps

5 ml of hydrochloric acid were added to 0.4 g of 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (prepared as described in Example 18), and then 0.23 g of tin powder was added to the resulting mixture, whilst stirring, after which the mixture was stirred at room temperature for a further hour. 10 ml of water were added to the reaction mixture, which was then extracted with methylene chloride. The methylene chloride layer was removed, and the aqueous layer was concentrated to dryness by evaporation under reduced pressure, and then crystallized from diethyl ether, to give a complex of the title compound with stannic chloride as a pale yellow powder in a yield of 72%.

Provenance & Evidence