alpha-Bromo-o-chlorotoluene → HCID 15289945, compound

HRID 1975707Notes

Reaction equation

[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[F:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][CH:12]=1.FC1C=CC=CC=1CBr.C1(C(Cl)=O)CCC1>>[F:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([CH2:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[Cl:1])=[O:16])=[CH:13][CH:12]=1

Participants

Reactant 4

HCID 11905alpha-Bromo-o-chlorotoluene

HCID 678794-Fluorobenzoyl chloride

HCID 67968alpha-Bromo-o-fluorotoluene

HCID 78705Cyclobutanecarbonyl chloride

Product 1

HCID 15289945HCID 15289945, compoundYield 34%

Procedure

Following a procedure similar to that described in Preparation 13, except that equivalent amounts of 2-chlorobenzyl bromide and 4-fluorobenzoyl chloride were used in place of the 2-fluorobenzyl bromide and cyclobutanecarbonyl chloride, the title compound was obtained as a colorless powder in a yield of 34%.

Sources & evidence

ORD record: ord-10f3568fa87448a4aee734cb693dc9c9
Source dataset: uspto-grants-1994_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05288726

Reaction notes

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