Tetrahydrofuran → HCID 9885239, compound

Participants

Reaction Conditions

Reaction Steps

2 g (5.8 mmol) of the compound from Example II are suspended in 6 ml of concentrated hydrochloric acid, and the suspension is stirred at 40° C. overnight. After cooling to room temperature, THF is added until solution is complete, and the solution is neutralised with sodium bicarbonate solution. The organic phase is separated off, dried with sodium sulphate and concentrated to a small volume in vacuo. Separation is carried out by column chromatography (silica gel 60, mobile phase: dichloromethane/ethyl acetate/glacial acetic acid 80/15/15).

Provenance & Evidence