HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaminophen → N-acetyl-4-(pyrid-2-ylmethoxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaminophen | HCID 1983 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | N-acetyl-4-(pyrid-2-ylmethoxy)aniline | HCID 19098335 | — |
Reaction Steps
A mixture of 4-acetamidophenol (120 g; 796 mmol), 2-picolyl chloride hydrochloride (130.6 g; 796 mmol), and powdered potassium carbonate (330 g; 2.39 mol) in 1500 mL DMF was stirred at ambient temperature for 7 days. The reaction was poured into brine and the precipitate was collected by vacuum filtration. The solids were washed with water followed by diethyl ether. The reaction yielded N-acetyl-4-(pyrid-2-ylmethoxy)aniline as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05288743 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-224274fc302a46e38bec89cd50e40e03 |
| Source note | uspto-grants-1994_02 |