HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 2-Bromo-5-(4-fluorobenzyl)thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-[(4-Fluorophenyl)methyl]thiophene | HCID 10583905 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Bromo-5-(4-fluorobenzyl)thiophene | HCID 10540013 | 98.1% |
Reaction Steps
The above thiophene (9.61 g, 50.0 mmol) was brominated using N-bromosuccinimide (8.90 g, 50.0 mmol) in CHCl3 and CH3COOH (1:1) to provide 13.3 g (98%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05288751 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-1540783ec3e945408592f798d5689d43 |
| Source note | uspto-grants-1994_02 |