Benzhydrylamine → HCID 10624052, compound

Participants

Reaction Conditions

Reaction Steps

A solution of [[[2,6-bis(1-methylethyl)phenyl]-amino]carbonyl]sulfamoyl chloride (1.0 g, 3.1 mmoles) in 60 mL Et2O was added dropwise to a solution of benzhydrylamine (0.56 g, 3.1 mmoles) and 0.5 mL triethylamine (3.4 mmoles) in 60 mL Et2O at -15° C. (acetone/ice bath) under an atmosphere of N2. The resulting suspension was warmed to 25° C. and stirred for 16 hours. This was then partitioned between 1N HCl and EtOAc. The EtOAc layer was dried with MgSO4, filtered, and evaporated to give an off-white solid. Chromatography (SiO2, 30% EtOAc/hexanes) gave 0.49 g (34%) of the title compound as a white solid, mp 182°-185° C.

Provenance & Evidence