HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionyl chloride → 3-(N-propionyl-N-n-propylamino)chroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | 3-(N-n-propylamino)chroman | HCID 19592108 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 3-(N-propionyl-N-n-propylamino)chroman | HCID 10848101 | 62% |
Reaction Steps
Propionyl chloride (2.8 g, 29 mmol) was added to a mixture of 15 (1.2 g, 6.4 mmol) in CH2Cl2 and 5% aqueous NaOH. The mixture was stirred for 30 min and separated. The organic layer was extracted with water, separated and dried (MgSO4). The crude product was chromatographed (SiO2) with light petroleum-ether (2:1) as eluant yielding 0.98 g (62%) of 3-(N-propionyl-N-n-propylamino)chroman (16).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05288748 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-102627aca7b4441bac4d72d68df5c88a |
| Source note | uspto-grants-1994_02 |