HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → 8-Chloro-2-(n-propylbenzoyl)amino-1,2,3,4-tetrahydronaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 8-chloro-2-(N-n-propylamino)tetralin | HCID 14969229 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Chloro-2-(n-propylbenzoyl)amino-1,2,3,4-tetrahydronaphthalene | HCID 19032662 | 95% |
Reaction Steps
To a solution of 53 g (0.23 mol) 8-chloro-2-(n-propyl)amino-1,2,3,4-tetrahydronaphthalene and 50 ml triethylamine in 500 ml dichloromethane was added dropwise 33 ml (40 g, 0.28 mol) benzoylchloride. After stirring over night at room temperature, 10% sodium carbonate was added and the mixture was shaken and separated. The organic phase was dried (magnesium sulphate), filtered and evaporated yielding 72 g (95%) raw product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05288748 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-5085cde565dd4687b94d649c15c06601 |
| Source note | uspto-grants-1994_02 |