Propionyl Acetophenone → 2-Ethyl-3-benzoyl-4-phenylpyrrole

HRID 1975774Notes

Reaction equation

HRID 1975774 reaction equation
[C:1]1([C:7]2[NH:8][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:10]1([C:16](=[O:22])[CH2:17][C:18](=O)[CH2:19][CH3:20])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(O)C>[CH2:19]([C:18]1[NH:8][CH:9]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:17]=1[C:16](=[O:22])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:20]

Participants

4

Reactant 2

HCID 21408Propionyl AcetophenoneHCID 190986582-Phenylazirine

Product 1

HCID 190986512-Ethyl-3-benzoyl-4-phenylpyrrole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The preparation is carried out in accordance with the general procedure in Example 1. The reactants are 2-phenylazirine and 1-phenylpentane-1,3-dione. The reaction product is dissolved in 150 ml of hot ethanol and the solution is allowed to stand overnight at room temperature. The precipitated crystals are filtered with suction.

Workup

  1. filtrationThe precipitated crystals are filtered with suction

Sources & evidence

ORD record
ord-1f9982d806b04a36840bc649003f268d
Source dataset
uspto-grants-1994_02
Patent number
US05288776

Reaction notes

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