HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1975817Generated: November 4, 2026
Sodium Hydroxide → 5-(Methoxymethyl)pyridine-2,3-dicarboxylic acid
https://huagongshe.com/reaction/1975817
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,3-Pyridinedicarboxylic acid, 5-(methoxymethyl)-, dimethyl ester | HCID 11096693 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(Methoxymethyl)pyridine-2,3-dicarboxylic acid | HCID 10998311 | 83.9% |
Reaction Steps
A mixture of dimethyl 5-(methoxymethyl)-2,3-pyridinedicarboxylate (60.0 g, 0.25 mol) and 50% sodium hydroxide solution (50.0 g, 0.63 mol) in water is heated at 90°-110° C. for 2 hours under nitrogen while distilling off methanol and water. The reaction mixture is cooled to 10° C. treated with sulfuric acid to adjust the pH to 2.0 and filtered to obtain a solid. The solid is washed with water and vacuum dried to give the title product as a white solid (44.3 g, mp 161°-162° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05288866 |
|---|
| Source dataset | uspto-grants-1994_02 |
|---|
| ORD ID | ord-cc51d386a0254a44aac4e49a81344ab9 |
|---|
| Source note | uspto-grants-1994_02 |
|---|
