Methyl isothiocyanate → HCID 15230793, compound

HRID 1975852Notes

Reaction equation

C([O:4][C:5]1[C:10]([C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:9][C:8]([CH:15]([NH:17][OH:18])[CH3:16])=[CH:7][C:6]=1[C:19]([CH3:22])([CH3:21])[CH3:20])(=O)C.[CH3:23][N:24]=[C:25]=[S:26]>>[CH3:21][C:19]([C:6]1[CH:7]=[C:8]([CH:15]([N:17]([OH:18])[C:25]([NH:24][CH3:23])=[S:26])[CH3:16])[CH:9]=[C:10]([C:11]([CH3:13])([CH3:12])[CH3:14])[C:5]=1[OH:4])([CH3:22])[CH3:20]

Participants

Reactant 2

HCID 11167Methyl isothiocyanate

HCID 54086794HCID 54086794, compound

Product 1

HCID 15230793HCID 15230793, compoundYield 55.4%

Procedure

To a solution of 0.500 g (0.0016 mole) of 2,6-bis(1,1-dimethylethyl)-4-[1-(hydroxyamino)ethyl]phenol acetate is added 0.128 g (0.00175) of methyl isothiocyanate. The reaction mixture is stirred at room temperature for 18 hours and evaporated to near dryness. The residue is washed with Et2O and there is obtained 0.300 g (55%) white solid, m.p. 175°-175.5° C.

Workup

customevaporated
washThe residue is washed with Et2O

Sources & evidence

ORD record: ord-75fec98abe5340d9b71cfd6e77a56b07
Source dataset: uspto-grants-1994_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05288896

Reaction notes

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