HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 4-(3,4-Dichlorophenyl)-1-piperazinepentanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5-Chlorovaleronitrile | HCID 80474 | — |
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | 4-(3,4-Dichlorophenyl)-1-piperazinepentanenitrile | HCID 21999698 | 72.1% |
Reaction Steps
A mixture of 1-(3,4-dichlorophenyl)piperazine (0.1 mol), 5-chloropentanenitrile (0.13 mol), sodium carbonate (10 g) and potassium iodide (0.1 g) in 4-methyl-2-pentanone (280 ml) was stirred and refluxed for 10 hours. The reaction mixture was cooled, filtered and the filtrate was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 95/5). The pure fractions were collected and the solvent was evaporated, yielding 22.5 g (72%) of 4-(3,4-dichlorophenyl)-1-piperazinepentanenitrile (interm. 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06224849B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-4a5bdc30be874aee83bdc8629aaa3da8 |
| Source note | uspto-grants-2001_05 |