HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N2-(tert-butoxycarbonyl)-N6-(iminomethoxymethyl)-L-lysine tert-butyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | N2-(tert-butoxycarbonyl)-N6-(cyano)-L-lysine tert-butyl ester | HCID 54448533 | — |
| Reactant | N2-(tert-butoxycarbonyl)-N5-(iminomethoxymethyl)-L-ornithine tert-butyl ester hydrochloride | HCID 86583874 | — |
| Reactant | HCID 178475094 | HCID 178475094 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N2-(tert-butoxycarbonyl)-N6-(iminomethoxymethyl)-L-lysine tert-butyl ester hydrochloride | HCID 86756656 | — |
Reaction Steps
From 1.6 g (4.89 mmol) N2-(tert-butoxycarbonyl)-N6-(cyano)-L-lysine tert-butyl ester was prepared 1.5 g (75%) of foamy solid N2-(tert-butoxycarbonyl)-N6-(ethoxyiminomethyl)-L-lysine tert-butyl ester hydrochloride by the method described for N2-(tert-butoxycarbonyl)-N5-(iminomethoxymethyl)-L-ornithine tert-butyl ester hydrochloride. TLC (methanol:dichloromethane/1:9) Rf=0.36. Mass spectrum (CI) 360 (MH+, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225305B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-fe3d865654e842d2a9289671a8cd7161 |
| Source note | uspto-grants-2001_05 |