Phosgene → HCID 178473407, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of N-(4-cyano-2-ethoxycarbonylamino-5-methyl-3-thienylsulfonyl)-N′-isopropylthiourea (0.3 g) and triethylamine (320 μl) in 10 ml of dry THF at 0° C. was added 750 μl of a 20% solution of phosgene in toluene. The mixture was stirred at 0° C. for 1 h and then evaporated to dryness. The residue was triturated with 10 ml of water, filtered off, rinsed on the filter with water and dried to give 0.24 g of crude title compound; m.p. 116-119° C. The product was used for the next step without purification.

Provenance & Evidence