Sodium Hydroxide → HCID 178435024, compound

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Reaction Steps

A mixture of ethyl 7-cyano-3-isopropylamino-6-methyl-4H-thieno[2,3-e]-1,2,4-thiadiazine-4-carboxylate 1,1-dioxide (0.15 g) and 5 ml of 1 M aqueous sodium hydroxide was stirred at room temperature for 1 h. Then the mixture was filtered and pH was adjusted to 1-2 by dropwise addition of 4M hydrochloric acid. After stirring for 30 min the precipitate was filtered off, rinsed with a small amount of water and dried to give the title compound; m.p. m.p. 235-238° C.; 1H-NMR (DMSO-d6) δ(ppm): 11.35 (s, 1H, NH), 7.55 (br d, 1H, NH), 3.98-3.77 (m, 1H, CH), 2.50 (s, 1H, CH3), 1.15 (d, 6H, CH3).

Provenance & Evidence